About the registry – PB Docs 2019

Some PowerBuilder features require the use of the PB.INI file,
but many features use the registry for getting and storing
configuration information. Normally, you should not need to access or
modify items in the registry directly.

Information related to your preferences (such as the
applications you have created, the way you have arranged your views in
the painters, and the shortcut keys you have defined for PowerBuilder
menu items) is stored in
HKEY_CURRENT_USER/Software/Sybase/PowerBuilder/19.0.

Installation-related information is stored in
HKEY_LOCAL_MACHINE/Software/Sybase/PowerBuilder/19.0.